Dr. Coelho at the Murray Lab, Harvard University. Image Source.
Today, Histories of Things to Come is very pleased to interview biochemist Dr. Miguel Costa Coelho, a Postdoctoral researcher at Harvard University, who has done ground-breaking research in the field of ageing. He is based at the Lab of Professor Andrew W. Murray and the FAS Center for Systems Biology at Harvard; and he is also affiliated with the Human Frontier Science Program.
Coelho's doctoral research at the Max Planck Institute in Germany traced the way a type of yeast actually gets younger as it ages. He found that when a stressed mother cell divided, it passed on all cellular junk associated with accumulated damage (the process we know as ageing) to one daughter cell, which died shortly thereafter. This left the other daughter cell pristine. Normally, both daughter cells would inherit cellular junk, allowing damage to accumulate in both over time. Coelho likened the outcome in this study to "the eternally young and beautiful Dorian Gray, and his corrupt and damaged portrait in the attic" (public access here; the full article is here).
There we have it, published 17 June 2014: under certain conditions, these yeast cells can grow toward immortality via compartmentalization, segregation and consequent elimination of progressive cellular damage as they divide over time. This finding was widely reported in the international press.